Pesquisa sobre:
SIRTUINS
Descritores Encontrados:
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DeCS
Descritor
Inglês
:
Sirtuins
Descritor
Espanhol
:
Sirtuinas
Descritor
Português
:
Sirtuínas
Sinônimos
Inglês
:
Sir2-like Proteins
Categoria:
D08.811.277.087.520.200.650
D08.811.913.400.725.115.961
D12.776.476.900
Definição
Inglês
:
A homologous
family
of regulatory
enzymes
that are structurally related to the protein silent mating type
information
regulator 2 (Sir2) found in
Saccharomyces cerevisiae
.
Sirtuins
contain a central catalytic core region which binds
NAD
. Several of the
sirtuins
utilize
NAD
to deacetylate
proteins
such as
HISTONES
and are categorized as
GROUP III HISTONE DEACETYLASES
. Several other sirtuin members utilize
NAD
to transfer ADP-RIBOSE to
proteins
and are categorized as MONO ADP-RIBOSE
TRANSFERASES
, while a third group of
sirtuins
appears to have both deacetylase and ADP
ribose
transferase activities.
Relacionados
Inglês
:
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Nota Histórica
Inglês
:
2003
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
37322
Identificador Único:
D037761
Ocorrência na BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS