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ALTEPLASE
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DeCS
Descriptor
English
:
Tissue Plasminogen Activator
Descriptor
Spanish
:
Activador de Tejido Plasminógeno
Descriptor
Portuguese
:
Ativador de Plasminogênio Tecidual
Synonyms
English
:
Tissue-Type Plasminogen Activator
Plasminogen Activator, Tissue-Type
Alteplase
T-Plasminogen Activator
Tree Number:
D08.811.277.656.300.760.875
D08.811.277.656.959.350.875
D12.776.124.125.662.768
D23.119.970
Definition
English
:
A proteolytic enzyme in the
serine
protease
family
found in many
tissues
which converts
PLASMINOGEN
to
FIBRINOLYSIN
. It has fibrin-binding activity and is immunologically different from
UROKINASE-TYPE PLASMINOGEN ACTIVATOR
. The primary sequence, composed of 527
amino acids
, is identical in both the naturally occurring and synthetic proteases.
Pharmacological Action:
Fibrinolytic Agents
History Note
English
:
98(86)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30438
Unique Identifier:
D010959
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS