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CALRETICULIN
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DeCS
Descriptor
English
:
Calreticulin
Descriptor
Spanish
:
Calreticulina
Descriptor
Portuguese
:
Calreticulina
Tree Number:
D12.644.360.381.374
D12.776.157.125.412.374
D12.776.476.387.374
D12.776.503.303
Definition
English
:
A multifunctional protein that is found primarily within membrane-bound
organelles
. In the
ENDOPLASMIC RETICULUM
it binds to specific N-linked
oligosaccharides
found on newly-synthesized
proteins
and functions as a MOLECULAR CHAPERONE that may play a
role
in
PROTEIN FOLDING
or retention and degradation of misfolded
proteins
. In addition
calreticulin
is a major storage form for
CALCIUM
and functions as a calcium-signaling molecule that can regulate intracellular
calcium
HOMEOSTASIS.
History Note
English
:
2003; use CALRETICULIN (NM) 1990-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37386
Unique Identifier:
D037282
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS