Search on: HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN K 
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Descriptor English:   Heterogeneous-Nuclear Ribonucleoprotein K 
Descriptor Spanish:   Ribonucleoproteína Heterogénea-Nuclear Grupo K 
Descriptor Portuguese:   Ribonucleoproteínas Nucleares Heterogêneas Grupo K 
Tree Number:   D12.776.157.725.500.500.500
D12.776.260.268
D12.776.664.962.500.500.500
Definition English:   A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties. 
Indexing Annotation English:   see SCR for specific hnRNP entries
History Note English:   2003; use HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K (NM) 1994-2002; for HNRNP K use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1994-2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   37415 
Unique Identifier:   D034641 

Occurrence in VHL:
 

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