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LEUKOTRIENE C4
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DeCS
Descriptor
English
:
Leukotriene C4
Descriptor
Spanish
:
Leucotrieno C4
Descriptor
Portuguese
:
Leucotrieno C4
Synonyms
English
:
LTC4
Tree Number:
D10.251.355.255.100.450.855.455
D23.469.050.175.450.725.400
Definition
English
:
The conjugation product of
LEUKOTRIENE A4
and
glutathione
. It is the major
arachidonic acid
metabolite in
macrophages
and human
mast cells
as well as in antigen-sensitized
lung
tissue. It stimulates
mucus
secretion in the
lung
, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From
Dictionary
of
Prostaglandins
and Related Compounds, 1990)
Indexing Annotation
English
:
/biosyn /physiol permitted; DF: note short X ref
History Note
English
:
94; was see SRS-A 1983-93; LEUKOTRIENE C1 & LEUKOTRIENES C were see SRS-A 1983-93
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
31350
Unique Identifier:
D017997
Occurrence in VHL
:
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