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METABOLIC DETOXICATION, PHASE I
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DeCS
Descriptor
English
:
Metabolic Detoxication, Phase I
Descriptor
Spanish
:
Fase I de la Desintoxicación Metabólica
Descriptor
Portuguese
:
Desentoxicação Metabólica Fase I
Tree Number:
G03.495.244.820.500
G07.690.812.097.600.500
G07.700.680.097.600.500
Definition
English
:
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I
enzymes
include CYTOCHROME P450
enzymes
and some
OXIDOREDUCTASES
. Excess induction of phase I over phase II detoxification leads to higher levels of
FREE RADICALS
that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of
DRUG INTERACTIONS.
See Related
English
:
Drug Interactions
History Note
English
:
2006
Allowable Qualifiers
English
:
EH
ethnology
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
51246
Unique Identifier:
D050216
Occurrence in VHL
:
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