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PLATELET GLYCOPROTEIN GPIB-IX COMPLEX
Descriptors Found:
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DeCS
Descriptor
English
:
Platelet Glycoprotein GPIb-IX Complex
Descriptor
Spanish
:
Complejo GPIb-IX de Glicoproteína Plaquetaria
Descriptor
Portuguese
:
Complexo Glicoproteico GPIb-IX de Plaquetas
Synonyms
English
:
Antigens, CD42a
Antigens, CD42b
Antigens, CD42c
Antigens, CD42d
CD42a Antigens
CD42b Antigens
CD42c Antigens
CD42d Antigens
Platelet Membrane Glycoprotein Ib
Platelet Membrane Glycoprotein IX
Platelet Membrane Glycoprotein V
Tree Number:
D12.776.395.550.625.460
D12.776.395.550.625.800.780
D12.776.543.550.625.460
D12.776.543.550.625.800.780
D12.776.543.750.705.675.568
Definition
English
:
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for
von Willebrand factor
and for
thrombin
. Congenital deficiency of the GPIb-IX complex results in
Bernard-Soulier syndrome
. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in
Bernard-Soulier syndrome.
Indexing Annotation
English
:
important in platelet aggreg; note X refs as CD42
antigens
; DF: GPIB IX
Entry Combination - descr/qualif
English
:
Platelet Glycoprotein GPIb-IX Complex
/
deficiency
use
Bernard-Soulier Syndrome
History Note
English
:
96; PLATELET MEMBRANE GLYCOPROTEIN IB was see PLATELET MEMBRANE GLYCOPROTEINS 1987-95
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
32648
Unique Identifier:
D019038
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS