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DeCS
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Descriptor English:
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Poly(A)-Binding Protein II
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Descriptor Spanish:
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Proteína II de Unión a Poli(A)
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Descriptor Portuguese:
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Proteína II de Ligação a Poli(A)
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Tree Number:
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D12.776.157.725.452.500
D12.776.664.962.452.500
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Definition English:
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A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL. |
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See Related English:
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Muscular Dystrophy, Oculopharyngeal
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History Note English:
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2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002
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Allowable Qualifiers English:
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Record Number:
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37408
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Unique Identifier:
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D039103
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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