Search on: PROTO-ONCOGENE PROTEINS C-RET 
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Descriptor English:   Proto-Oncogene Proteins c-ret 
Descriptor Spanish:   Proteínas Proto-Oncogénicas c-ret 
Descriptor Portuguese:   Proteínas Proto-Oncogênicas c-ret 
Synonyms English:   c-ret Protein
ret Proto-Oncogene Proteins  
Tree Number:   D08.811.913.696.620.682.725.400.087
D12.776.543.750.060.217
D12.776.624.664.700.194
Definition English:   Receptor protein-tyrosine kinases involved in the signaling of GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR ligands. They contain an extracellular cadherin domain and form a receptor complexes with GDNF RECEPTORS. Mutations in ret protein are responsible for HIRSCHSPRUNG DISEASE and MULTIPLE ENDOCRINE NEOPLASIA TYPE 2. 
History Note English:   2006(1999) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   50737 
Unique Identifier:   D051096 

Occurrence in VHL: 		 

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