Search on: PYRROLINE CARBOXYLATE REDUCTASES 
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Descriptor English:   Pyrroline Carboxylate Reductases 
Descriptor Spanish:   Pirrolina Carboxilato Reductasas 
Descriptor Portuguese:   Pirrolina Carboxilato Redutases 
Tree Number:   D08.811.682.662.695
Definition English:   A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD(P)H. Includes both the 2-oxidoreductase (EC 1.5.1.1) and the 5-oxidoreductase (EC 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline. 
History Note English:   91(77); was see under AMINE OXIDOREDUCTASES 1977-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   12199 
Unique Identifier:   D011762 

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