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DeCS
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Descriptor English:
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RNA-Binding Protein FUS
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Descriptor Spanish:
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Proteína FUS de Unión a ARN
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Descriptor Portuguese:
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Proteína FUS de Ligação a RNA
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Synonyms English:
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FUS RNA-Binding Protein
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Tree Number:
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D12.776.157.725.500.500.905
D12.776.624.664.700.915
D12.776.664.962.500.500.902
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Definition English:
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A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia. |
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History Note English:
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2003; for FUS PROTEIN & HNRNP P2 use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1996-2002; for TLS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1993-2002;
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Allowable Qualifiers English:
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Record Number:
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37420
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Unique Identifier:
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D034702
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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