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RNA-INDUCED SILENCING COMPLEX
Descriptors Found:
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DeCS
Descriptor
English
:
RNA-Induced Silencing Complex
Descriptor
Spanish
:
Complejo Silenciador Inducido por ARN
Descriptor
Portuguese
:
Complexo de Inativação Induzido por RNA
Tree Number:
D08.811.277.352.355.350.810
D08.811.277.352.700.350.810
D12.776.157.725.500.906
D12.776.664.962.500.906
Definition
English
:
A multicomponent, ribonucleoprotein complex comprised of one of the
family
of
ARGONAUTE PROTEINS
and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating
gene expression
are determined by the specific argonaute protein and small
RNA
including siRNA (
RNA
, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING
RNA
).
See Related
English
:
RNA Interference
RNA, Small Interfering
History Note
English
:
2003; use RNA-INDUCED SILENCING COMPLEX (NM) 2001-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37323
Unique Identifier:
D034743
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS