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GRANZYMES
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DeCS
Descriptor
English
:
Granzymes
Descriptor
Spanish
:
Granzimas
Descriptor
Portuguese
:
Granzimas
Tree Number:
D08.811.277.656.300.760.397
D08.811.277.656.959.350.397
Definition
English
:
A
family
of
serine endopeptidases
found in the SECRETORY GRANULES of
LEUKOCYTES
such as CYTOTOXIC
T-LYMPHOCYTES
and NATURAL KILLER
CELLS
. When secreted into the intercellular space
granzymes
act to eliminate transformed and virus-infected host
cells.
Pharmacological Action:
Cytotoxins
History Note
English
:
2007(1986)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52244
Unique Identifier:
D053804
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS