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AROMATASE
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DeCS
Descriptor
English
:
Aromatase
Descriptor
Spanish
:
Aromatasa
Descriptor
Portuguese
:
Aromatase
Synonyms
English
:
Cytochrome P-450(AROM)
Cytochrome P-450 CYP19
CYP19
Tree Number:
D08.244.453.915.099
D08.811.682.690.708.170.915.099
D08.811.682.690.708.783.099
D12.776.422.220.453.915.099
Definition
English
:
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19
androgens
and converts them to C18
estrogens
. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the
endoplasmic reticulum
of estrogen-producing
cells
of ovaries,
placenta
, testes, adipose, and
brain
tissues
.
Aromatase
is encoded by the CYP19 gene, and functions in complex with
NADPH-FERRIHEMOPROTEIN REDUCTASE
in the cytochrome P-450 system.
Entry Combination - descr/qualif
English
:
Aromatase
/
antagonists & inhibitors
use
Aromatase Inhibitors
History Note
English
:
86(75); was see under OXIDOREDUCTASES 1975-85
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23161
Unique Identifier:
D001141
Occurrence in VHL
:
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CID-10
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