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DIDANOSINE
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DeCS
Descriptor
English
:
Didanosine
Descriptor
Spanish
:
Didanosina
Descriptor
Portuguese
:
Didanosina
Synonyms
English
:
ddI (Antiviral)
2',3'-Dideoxyinosine
Dideoxyinosine
Tree Number:
D03.438.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
Definition
English
:
A dideoxynucleoside compound in which the 3'-hydroxy group on the
sugar
moiety has been replaced by a
hydrogen
. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains.
Didanosine
is a potent inhibitor of
HIV
replication, acting as a chain-terminator of viral
DNA
by binding to reverse transcriptase; ddI is then metabolized to
dideoxyadenosine
triphosphate, its putative active metabolite.
Pharmacological Action:
Anti-HIV Agents
Antimetabolites
Reverse Transcriptase Inhibitors
History Note
English
:
92; was DIDEOXYINOSINE 1990-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
30328
Unique Identifier:
D016049
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS