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FERROCHELATASE
Descriptors Found:
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DeCS
Descriptor
English
:
Ferrochelatase
Descriptor
Spanish
:
Ferroquelatasa
Descriptor
Portuguese
:
Ferroquelatase
Synonyms
English
:
Heme Synthetase
Porphyrin-Metal Chelatase
Tree Number:
D08.811.520.500
D12.776.157.427.374.375.957
D12.776.556.579.374.375.617
D12.776.575.562
Definition
English
:
A mitochondrial enzyme found in a wide variety of
cells
and
tissues
. It is the final enzyme in the 8-enzyme biosynthetic pathway of
HEME
.
Ferrochelatase
catalyzes ferrous insertion into protoporphyrin IX to form protoheme or
heme
. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Entry Combination - descr/qualif
English
:
Ferrochelatase
/
deficiency
use
Protoporphyria, Erythropoietic
History Note
English
:
1991(1977); use LYASES 1977-1990
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
5403
Unique Identifier:
D005294
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS