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INTERLEUKIN-12
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DeCS
Descriptor
English
:
Interleukin-12
Descriptor
Spanish
:
Interleucina-12
Descriptor
Portuguese
:
Interleucina-12
Synonyms
English
:
Edodekin Alfa
IL-12
Natural Killer Cell Stimulatory Factor
Tree Number:
D12.644.276.374.465.512
D12.776.467.374.465.512
D23.529.374.465.512
Definition
English
:
A heterodimeric cytokine that plays a
role
in innate and adaptive immune responses.
Interleukin-12
is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by
DENDRITIC CELLS
;
MACROPHAGES
and a variety of other immune
cells
and plays a
role
in the stimulation of
INTERFERON-GAMMA
production by
T-LYMPHOCYTES
and NATURAL KILLER
CELLS.
Indexing Annotation
English
:
DF: IL 12 or IL12
Pharmacological Action:
Adjuvants, Immunologic
Angiogenesis Inhibitors
See Related
English
:
Immunity, Cellular
History Note
English
:
1995(1995)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
32173
Unique Identifier:
D018664
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS